Fibrinogen and coronary heart disease: test of causality by ‘Mendelian randomization’

Mendelian randomization of blood lipids for coronary heart disease

AIMS To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. METHODS AND RESULTS We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein chole...

Mendelian randomization studies in coronary artery disease.

Epidemiological research over the last 50 years has discovered a plethora of biomarkers (including molecules, traits or other diseases) that associate with coronary artery disease (CAD) risk. Even the strongest association detected in such observational research precludes drawing conclusions about the causality underlying the relationship between biomarker and disease. Mendelian randomization (...

Running Head: Mendelian Randomization Using Genetic Information to Infer Causality in Observational Data: Mendelian Randomization

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

Background We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. Methods We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for I...

Circulating cholesteryl ester transfer protein and coronary heart disease: mendelian randomization meta-analysis.

BACKGROUND The cholesteryl ester transfer protein (CETP) plays a central role in reverse cholesterol transport. Currently, it remains unresolved whether circulating CETP is causally associated with coronary heart disease (CHD). We aimed to investigate this causal association using CETP gene rs708272 polymorphism as an instrument in a Mendelian randomization meta-analysis. METHODS AND RESULTS ...